Southern Nana’s Meatloaf – Tender, Juicy & Full of Love 🍽️❤️

There’s nothing quite like the comforting smell of meatloaf baking in the oven. This recipe for Southern Nana’s Meatloaf is a timeless classic passed down through generations. Made with simple ingredients and a sweet, tangy glaze, it’s the kind of dish that turns an ordinary dinner into a comforting, home-cooked meal.
Moist on the inside with a perfectly caramelized crust on the outside, this meatloaf is everything you crave in Southern comfort food.
Ingredients
- 2 lbs ground beef (80/20 works best)
- 1 cup breadcrumbs or crushed saltine crackers
- 1 small onion, finely chopped
- 1 green bell pepper, finely chopped (optional but traditional)
- 2 large eggs
- ¾ cup milk
- 2 tablespoons Worcestershire sauce
- 1 teaspoon garlic powder
- 1 teaspoon salt
- ½ teaspoon black pepper
For the Glaze
- ½ cup ketchup
- 2 tablespoons brown sugar
- 1 tablespoon yellow mustard
- 1 teaspoon apple cider vinegar (optional for tang)
Instructions
- Preheat oven to 375°F (190°C).
- In a large bowl, combine ground beef, breadcrumbs, onion, bell pepper, eggs, milk, Worcestershire sauce, garlic powder, salt, and pepper. Mix gently with your hands until combined—don’t overmix to keep it tender.
- Shape the mixture into a loaf and place it on a greased or parchment-lined baking sheet, or in a loaf pan for a more traditional shape.
- In a small bowl, whisk together ketchup, brown sugar, mustard, and vinegar to make the glaze. Spread half the glaze over the top of the meatloaf.
- Bake for 45 minutes, then spread the remaining glaze over the meatloaf and return to the oven. Bake for another 15–20 minutes, or until the internal temperature reaches 160°F (71°C).
- Let it rest for 5–10 minutes before slicing. This helps the juices redistribute and keeps the meatloaf moist.
Serving Tip
Pair with creamy mashed potatoes, green beans, or Southern-style mac and cheese for the perfect comforting meal.
FAQs
Q: Can I substitute ground turkey or pork?
Yes, but beef gives the classic flavor. Turkey works for a leaner option—just add a bit more seasoning.
Q: What keeps it from falling apart?
The breadcrumbs and eggs act as binders to hold everything together.
Q: Can I freeze leftovers?
Absolutely. Slice and wrap pieces individually for quick meals later.
Southern Nana’s Meatloaf is more than just dinner—it’s a warm memory on a plate, filled with love and tradition.



